Energy use glucose to nourish the cells that make insulin. A spoonful of sugar glucose may be a solution for the treatment of diabetes. The
more supply of glucose to the cells that make insulin in the pancreas,
the cloned cells more quickly, according to research results on mice
suggests.
Dr. Yuval Dor
Dr. Yuval Dor
These findings, published in the journal Cell Metabolism,
of the April 6, 2011, may help researchers make new treatments for all
patients with diabetes type 1 and type 2 , by exploiting the mechanisms
leading to cell growth by fueling glucose.
This is seen as a strategy that can help restore function to the
insulin-producing cells, damaged pancreas in diabetic patients, while
avoiding the toxic effects caused by blood sugar high.
Animals eat more food or sought for cells exposed to glucose, sugar to fuel cell operation, this job will increase the number of insulin-producing cells in also known as pancreatic beta cells. But the exact mechanism how that glucose increases the number of beta cells remains poorly understood clearly.
"This is not a simple question to clarify," said Patricia Kilian, director of the Research Foundation of children with diabetes. "It is related to many factors." In fact, many researchers suspect that the glucose is the main factor responsible for the growth of beta cells, because glucose can kill cells (which is why blood sugar high is very dangerous for diabetics). The result of this research is truly important contribution to understanding how to restore the function of the pancreas, according to Patricia Kilian.
In this study, the researchers, led by Yuval Dor and Benjamin Glaser, worked at the Hebrew University in Jerusalem, Israel, have used genetic engineering to destroy 80% of the beta cells in the pancreas of mice. The mouse has now fallen into the state can not produce enough insulin and thus we get sick with diabetes, but in the period from 4 to 6 weeks later, blood glucose levels of the mice returned normal. The researchers discovered that a number of beta cells developed back.
"Beta cells, contrary to expectations, its regenerative capacity is very slow and very weak. It is a defect in diabetes," said Yuval Dor, a developmental biologist.
Yuval Dor and his colleagues wanted to find out whether the slow growth of beta cells has been driven by the amount of sugar in the blood of mice or due to other factors. To find out, the researchers killed about 80% of the beta cells in a group of mice, but this time the researchers transplanted insulin-producing cells in other places, in order to help rats keep blood sugar at normal levels. That means that the beta cells in the pancreas survived not work hard. The researchers found that the rate of regeneration of beta cells decreased with the workload fairly relaxed for the beta cells in the pancreas. These results helped the researchers to conclude that glucose was actually involved in the regeneration of beta cells.
To confirm the certainty of the findings, the researchers did find and remove an enzyme called glucokinase from the beta cells of the mouse. Glucokinase is an important enzyme in the conversion of glucose into energy. Without glucokinase "beta cell replication was reduced almost to zero," Dor said. That told the researchers that processing capability of the cell lines is important.
This result also suggests that the drugs have the effect of enhancing the activity of glucokinase can also increase the growth of beta cells. The researchers tested a glucokinase drugs and medications that can promote the production of beta cells in mice. Those who have the change increases the activity of glucokinase in their pancreatic beta cells will have many more.
The same drug may help patients with diabetes, the beta cells are only a few functions, this time to heal their pancreas, an important step to healing. These drugs may promote the growth of beta cells while reducing the flow of blood sugar. The next step is to understand the whole biological processes related to how glucose promote the recovery of the beta cells, Dor said.
Animals eat more food or sought for cells exposed to glucose, sugar to fuel cell operation, this job will increase the number of insulin-producing cells in also known as pancreatic beta cells. But the exact mechanism how that glucose increases the number of beta cells remains poorly understood clearly.
"This is not a simple question to clarify," said Patricia Kilian, director of the Research Foundation of children with diabetes. "It is related to many factors." In fact, many researchers suspect that the glucose is the main factor responsible for the growth of beta cells, because glucose can kill cells (which is why blood sugar high is very dangerous for diabetics). The result of this research is truly important contribution to understanding how to restore the function of the pancreas, according to Patricia Kilian.
In this study, the researchers, led by Yuval Dor and Benjamin Glaser, worked at the Hebrew University in Jerusalem, Israel, have used genetic engineering to destroy 80% of the beta cells in the pancreas of mice. The mouse has now fallen into the state can not produce enough insulin and thus we get sick with diabetes, but in the period from 4 to 6 weeks later, blood glucose levels of the mice returned normal. The researchers discovered that a number of beta cells developed back.
"Beta cells, contrary to expectations, its regenerative capacity is very slow and very weak. It is a defect in diabetes," said Yuval Dor, a developmental biologist.
Yuval Dor and his colleagues wanted to find out whether the slow growth of beta cells has been driven by the amount of sugar in the blood of mice or due to other factors. To find out, the researchers killed about 80% of the beta cells in a group of mice, but this time the researchers transplanted insulin-producing cells in other places, in order to help rats keep blood sugar at normal levels. That means that the beta cells in the pancreas survived not work hard. The researchers found that the rate of regeneration of beta cells decreased with the workload fairly relaxed for the beta cells in the pancreas. These results helped the researchers to conclude that glucose was actually involved in the regeneration of beta cells.
To confirm the certainty of the findings, the researchers did find and remove an enzyme called glucokinase from the beta cells of the mouse. Glucokinase is an important enzyme in the conversion of glucose into energy. Without glucokinase "beta cell replication was reduced almost to zero," Dor said. That told the researchers that processing capability of the cell lines is important.
This result also suggests that the drugs have the effect of enhancing the activity of glucokinase can also increase the growth of beta cells. The researchers tested a glucokinase drugs and medications that can promote the production of beta cells in mice. Those who have the change increases the activity of glucokinase in their pancreatic beta cells will have many more.
The same drug may help patients with diabetes, the beta cells are only a few functions, this time to heal their pancreas, an important step to healing. These drugs may promote the growth of beta cells while reducing the flow of blood sugar. The next step is to understand the whole biological processes related to how glucose promote the recovery of the beta cells, Dor said.
The drugs promote beta cell growth can also be helpful for diabetic
patients were transplanted islet cells in the pancreas, Kilian said.
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